The skin care market is a key segment of the global beauty industry. TRI has leading edge skills and capabilities in vibrational spectroscopies (Infra-red and Raman spectroscopy) which we use to measure a wide range of skin properties and skin treatment effects in the laboratory, in pre-clinical tests, in vivo and clinical settings (in partnership with clinical testing companies). TRI also offers skin cell culture studies and in vitro skin penetration studies. TRI reports are recognized by clients, regulators and advertising authorities around the world as being unbiased and of high quality.
TRI offers a wide range of skin testing methods to clients for research studies, pre-clinical studies, clinical studies and for claim support.
Skin Anti-Aging · Collagen & Elastin Production
Fibroblast Cell Culture
The density of collagen and elastin in the dermis is well known to reduce with chronological aging. Tests on dermal fibroblast cell cultures can investigate the effects of actives on stimulating the production of these important structural proteins.
Active Penetration · Quantification
Diffusion Cell Experiments
The clinical efficacy of any cosmetic or medicinal skin active is determined not only by its intrinsic activity, but also by its delivery to the site of action. Pre-clinical skin delivery studies are, therefore, essential in ensuring that active delivery is maximized and that clinical tests are successful.
Skin Natural Moisturizing Factor (NMF) Levels
An absence of NMF is believed to be linked to skin problems, such as skin dryness and atopic dermatitis (eczema). If you are interested in measuring the levels of NMF to investigate the effects of skin treatments, you might consider using TRI’s unique, tape-stripping and spectroscopy technique.
Lipid Barrier Structure & Integrity
The way intercellular lipids are packed and organized in the stratum corneum is absolutely vital for their function. Using unique spectroscopic techniques, TRI is able to explore these lipid packing arrangements.
Sebum Levels & Composition
TRI uses FTIR spectroscopy to measure the sebum levels in vivo without the need for any sebum extraction processes. The flexibility provided by the optical probe attached to the IR spectrometer makes it easy to investigate all parts of the body, including the scalp.
In order to fully address client and consumer needs, TRI has developed unique protocols to assess product effects and to assist in claims development.
Protection from Sunlight (UV) · Lipid Barrier Integrity
TRI protocols for the measurement of SC lipid barrier organization, using FTIR spectroscopy, are used to measure UV effects. Our methods clearly show an increase in lipid disorder with increasing UV exposure and can be used to screen sunscreen effects.
Protection from Gaseous Pollution · Lipid Barrier Integrity
TRI has new custom-built exposure chambers suitable for use both in vivo and ex vivo to test effects of ozone and nitric oxides on skin.